The amygdala – piriform region plays a central role in olfaction (Buchanan et al., 2003; Gottfried, 2010). The allocortex (amygdala and piriform cortex) and related piriform periallocortex receive projections from the olfactory bulb (Sakamoto, 1999). Deep amygdala nuclei seem to be involved in emotional processing of olfactory stimuli (Anderson et al., 2003). The region is...
Functional specialization and integration of the human cortex are two basic principles in neuroscience. For decades, significant efforts have been made to explore the underlying mechanisms of these principles based on a broad range of neuroanatomical and neuroimaging features. However, the spatial patterning of cortical organization and the interrelationships between different regions are...
Imaging technologies are increasingly used to generate high-resolution reference maps of brain structure and function. Comparing experimentally generated maps to these reference maps facilitates cross-disciplinary scientific discovery. Although recent data sharing initiatives increase the accessibility of brain maps, data are often shared in disparate coordinate systems, precluding systematic...
High-resolution light-microscopic scans of histological brain sections allow identifying cytoarchitectonic areas. They are defined by the local characteristics of microstructural organization, which encompasses the size, type, shape, and distribution of neurons, as well as their distinct laminar and columnar organization. As established brain mapping methods relying on statistical image...
Neuropil represents the fundamental unit in which cellular signals are processed, and it consists of neuronal/glial cells whose finest filaments form synapses. Thus, neuropil density (NP) combines both cellular (i.e., neuronal/glial cells) and synaptic masses and is central to understanding the heterogeneity of brain metabolism. Current bottom-up energy atlases use NP-derived neuronal (NeuDen)...
The current variety of data from neuronal recordings paves the way to complementary approaches for understanding brain activity. At the same time, this poses the challenge to consistently compare data across experiments, species, and spatio-temporal scales, promoting the integration of multiple approaches from different neuroscience sub-domains. Also, experimental data are essential to...
Introduction
The BigBrain model [1] is a cornerstone for extracting quantitative measures of brain architecture at 20μm isotropic resolution. While this model has proven instrumental in extracting 3D histological features, there's a growing need for even higher spatial resolution to obtain measures at the level of individual cells. Building on previous work from 2022 [2], this project...
This paper considers the generic problem of dense alignment between two images, whether they be two frames of a video, two widely Different views of a scene, two paintings depicting similar content, etc. Whereas each such task is typically addressed with a domain-specific the solution, Near-duplicates interpolation or alignment, is an interesting new application, but large motion challenges...
The hypothalamus is a brain structure that plays a central role in maintaining homeostasis and regulating various physiological and behavioural processes. It encompasses distinct nuclei with diverse microstructure, connectivity, molecular structure and functions, including circadian rhythm regulation, sleep-wake cycles, appetite control, stress response, and thermoregulation. Dysfunctions of...
The cerebral cortex shows subtle left-right morphological asymmetry supporting hemispheric specialization of functional processes including attention and language, which is also associated with neuropsychiatric conditions. However, previous studies consider gray matter as a morphological feature rather than a laminar structure to study asymmetry. Here, we leveraged intensity profiles from...
Introduction: Adolescence is a period of ongoing brain reorganization that is essential to biological and psychosocial maturation, but also to mental health (Paus et al., 2008). Adolescent brain maturation as captured via neuroimaging follows two main modes: 1) conservative strengthening of initially strong inter-regional similarities, or 2) disruptive remodeling, i.e. strengthening of...
Regulation of cortical microcircuits is crucial for optimal neural processing. Adolescence involves substantial macro- and microscale changes in the brain, including maturation of cortical microcircuits. Evidence from animal studies suggests a calibration of cortical microcircuits and excitation-to-inhibition (E-I) ratio during adolescence. However, in-vivo measurement of cortical...
