Sep 21 – 23, 2021
Virtual
Europe/Berlin timezone

Genetic and phylogenetic uncoupling of microstructure and function in human transmodal cortex

Sep 23, 2021, 4:00 PM
1h 30m
Virtual

Virtual

Board: 36
Poster Poster and Demo Session Poster and Demo Session

Speaker

Dr Sofie Valk (Institute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Forschungszentrum Jülich)

Description

Brain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. To evaluate the association between structure and function we assessed whether regions with similar microstructure would also be functionally connected in humans and macaques. This microstructural profile similarity approach has been previously developed in the big brain (Paquola, 2018). In humans, structure-function coupling was highest in regions of unimodal cortex and lowest in transmodal cortex. Structure-function uncoupling in non-human primates had a similar spatial distribution, but we observed an increased coupling between structure and function in association regions in macaques relative to humans.

Primary authors

Dr Sofie Valk (Institute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Forschungszentrum Jülich) Dr Ting Xu (Center for the Developing Brain ) Dr Casey Paquola (Institute of Neuroscience and Medicine, Structural and functional organisation of the brain (INM-1), Forschungszentrum Jülich) Dr Bo-yong Park (Multimodal Imaging and Connectome Analysis Lab, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University) Dr Richard A.I. Bethlehem (Department of Psychiatry, Cambridge University) Dr Reinder Vos de Wael (Multimodal Imaging and Connectome Analysis Lab, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University) Jessica Royer (Multimodal Imaging and Connectome Analysis Lab, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University) Dr Shahrzad Kharabian Masoule (Institute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Forschungszentrum Jülich) Şeyma Bayrak (Otto Hahn Group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences) Dr Peter Kochunov (Maryland Psychiatric Research Center, University of Maryland School of Medicine) Dr B.T. Thomas Yeo (Department of Electrical and Computer Engineering, National University of Singapore) Prof. Daniel Margulies (Neuroanatomy and Connectivity Lab, Institut de Cerveau et de la Moelle epiniere) Prof. Jonathan Smallwood (Department of Psychology, Queen’s University) Prof. Simon B. Eickhoff (Institute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Forschungszentrum Jülich) Dr Boris C. Bernhardt (McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University )

Presentation materials

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