Spatial omics technologies enable the study of molecular distribution patterns within the brain, offering critical insights into cellular organization and function. A significant challenge in this field is accurately mapping spatial omics data onto existing 3D brain atlases. Successful mapping would facilitate multimodal atlas creation, allow precise transfer of brain area labels from atlases...
Background. The claustrum is a thin, sheet-like grey matter structure nestled between the putamen and insula, wrapped by the capsulae externa and extrema. It is among the most highly connected brain regions, with reciprocal projections spanning the cortical mantle. But claustral function is underinvestigated in living humans, as its complex three-dimensional architecture is poorly...
Intracortical microstructure profiling represents a powerful, scalable approach for investigating the laminar organisation of the human cortex on both post-mortem and in-vivo datasets. Building upon a long tradition of histological analysis, this method leverages advances in high-resolution MRI and surface-based sampling to generate quantitative profiles of tissue properties across cortical...
Introduction:
In 2013, we published BigBrain1, a high-resolution (20μm^3) histological 3D-reconstructed model of the human brain (Amunts et al., 2013). Over the past several years, focus has been directed towards advances in the reconstruction and analysis of BigBrain2 (Mohlberg et al., 2022; Lepage et al., 2023; Lewis et al., 2024; Mohlberg, Lepage et al., 2025).
However,...
The hippocampus is an extension of the neocortex with highly convoluted folding that varies between individuals. This variability presents a significant shape-fitting challenge that must be addressed for precise inter-individual alignment, parcellation, and detailed mapping of hippocampal structure and function. We previously developed HippUnfold, which uses deep neural networks to segment...
Understanding mechanisms of brain function and dysfunction is at the core of the neuroscience mission. However, our grasp of causal relationships between brain properties is hindered by a historical focus on single modalities neglecting the complex interplay between neural scales and features. Progress in neuroinformatics and the increasing availability of open datasets such as BigBrain have...
