23–24 Jun 2022
Virtual
Europe/Berlin timezone

Simulation of optogenetic based visual prosthetic stimulation in V1

K-1
23 Jun 2022, 09:35
45m
Virtual

Virtual

Keynote Main track Keynote

Speaker

Ján Antolik (Charles University)

Description

The neural encoding of visual features in primary visual cortex (V1) is well understood, with strong correlates to low-level perception, making V1 a suitable target for vision restoration through neuroprosthetics. However, the functional relevance of neural dynamics evoked through external stimulation directly imposed at the cortical level remains poorly understood. In the talk I will present results from our recent simulation study (Antolik et al. 2021) that combined (1) a large-scale spiking neural network model of cat V1 and (2) a virtual prosthetic system that drives in situ optogenetically modified cortical tissue with a matrix light stimulator. We designed a protocol for translating simple Fourier contrasted visual stimuli (gratings) into activation patterns of the optogenetic matrix stimulator. We characterised the relationship between the spatial configuration of the imposed light pattern and the induced cortical activity. Our simulations show that in the absence of visual drive (simulated blindness) optogenetic stimulation with a spatial resolution as low as 100 μm is sufficient to evoke activity patterns in V1 close to those evoked by normal vision. I will also discuss our recent unpublished effort to expand the simulations with neuron morphology dependent aspects of optogenetic light stimulation of neural tissue.

Acknowledgements

This material is based upon work supported by the Defense Advanced Research Projects Agency under Contract No. HR0011-17-C-0038 and the French National Research Agency (ANR-43 Horizontal-V1; ANR-17-CE37-0006). The research stay of JA at the Charles University is funded by the project (CZ.02.2.69/0.0/0.0/17_050/0008466) Improvement of internationalization in the field of research and development at Charles University, through the support of quality projects MSCA-IF.

Preferred form of presentation Talk & (optional) poster
Topic area models and applications
Speaker time zone UTC+1
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I agree to the declaration of honor Yes

Primary authors

Ján Antolik (Charles University) Mr Sabatiere Quentin (Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012, Paris, France) Mr Charlie Galle (Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012, Paris, France) Prof. Yves Frégnac (Unité de Neurosciences, Information et Complexité (UNIC), NeuroPSI, Gif-sur-Yvette, France) Prof. Ryad Benosman (Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012, Paris, France)

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