Presenter: Giulia Rossetti1,2,3
Team: Rui Pedro Ribeiro1, Jonas Goßen1, and Alejandro Giorgetti1,4
1 IAS-5 / INM-9, Forschungszentrum Jülich, Germany; 2 Jülich Supercomputing Center, Forschungszentrum Jülich, Germany; 3 University Hospital Aachen, RWTH Aachen, Germany; 4 Department of Biotechnology, University of Verona, Italy
By merging structural macromolecular data with systems biology...
Realistic models of human brain function and disease require high detail, human-specific knowledge of brain architecture. The BigBrain data set has established a new standard for uniform, high resolution, rigorous maps of the human brain. We set out to expand this development, by integrating multimodal mapping of fibers and molecularly defined cell types. For this, we use updated...
Stacking memory and transistors in 3D is a kind of Graal for computer chip design, which could speed up transit times much beyond what is possible with 2D design. Cortical folding is the trick found by nature to achieve this goal. Each brain however has a specific cortical folding pattern, as unique as a fingerprint. This talk will describe a research program aiming at deciphering this...
Brain segregation has been in the focus of research for more than 120 years. It has early been understood that the microstructural organization is closely linked to brain function and behavior, as formulated in early cytoarchitectonic (Brodmann, 1909), or myeloarchitectonic studies (Vogt and Vogt, 1919). Although Brodmann and the Vogts were working together in one lab, their cyto- and...
The brain has a complex cellular environment, with a tight crosstalk between multiple cell types that is critical for its correct function. Despite extensive research much remains unknown regarding the effect and dynamics of the cellular environment of the brain on the progression of disease, especially in the context of progressive neurodegenerative diseases such as Alzheimer’s Disease (AD)....
It is essential to map structural changes in subcortical brain regions to gain a better understanding of their function in both health and disease. We developed a method for quantifying microstructure profiles in vivo in a single human brain. Our results demonstrate that spatial profiles in the putamen, caudate globus pallidus, and midbrain are robustly reproduced across individuals, clinical...
What is the best way to understand the talking brain? Optimally, it is a computational model that has all the known neural properties, from which all known language phenomena are derivable. How close are we to this desideratum? Some argue that we are rather close, and present successes in the field of Natural Language Processing (NLP), as well as in neurolinguistics. I will review some large...
Omics sciences (e.g. genomics, proteomics, and interactomics) are gaining an increasing interest in the scientific community due to the availability of novel, high throughput platforms for the investigation of the cell machinery, and have a central role in the so called P4 (predictive, preventive, personalized and participatory) medicine.
High-throughput experimental platforms and clinical...
